Meropenem-Clavulanic Acid Has High In Vitro Activity against Multidrug-Resistant Mycobacterium tuberculosis
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Meropenem - clavulanic acid has high in vitro activity against multidrug - 1 resistant Mycobacterium tuberculosis
18 We investigated the activity of meropenem-clavulanic acid (MEM-CLA) against 68 M. 19 tuberculosis isolates. We included predominantly multiand extensively drug-resistant 20 tuberculosis isolates (MDR/XDR-TB), since the activity of MEM-CLA for resistant isolates 21 has not been studied extensively previously. Using Middlebrook 7H10 medium, all but four 22 isolates showed a MIC distribution of...
متن کاملMeropenem-clavulanic acid shows activity against Mycobacterium tuberculosis in vivo.
The carbapenems imipenem and meropenem in combination with clavulanic acid reduced the bacterial burden in Mycobacterium tuberculosis-infected macrophages by 2 logs over 6 days. Despite poor stability in solution and a short half-life in rodents, treatment of chronically infected mice revealed significant reductions of bacterial burden in the lungs and spleens. Our results show that meropenem h...
متن کاملMeropenem-clavulanate has high in vitro activity against multidrug-resistant Mycobacterium tuberculosis.
AIMS AND OBJECTIVES With the relentless increase in multidrug- and extensively-drug resistant tuberculosis (MDR/XDR-TB), new treatment strategies are necessary. Favorable results have been reported by combining a β-lactam antibiotic and a β-lactamase inhibitor. The β-lactamase encoded by the blaC gene of Mycobacterium tuberculosis (MTB) is the major mechanism of resistance to β-lactam antibioti...
متن کاملIs there a place for β-lactams in the treatment of multidrug-resistant/extensively drug-resistant tuberculosis? Synergy between meropenem and amoxicillin/clavulanate.
OBJECTIVES To: (i) assess if amoxicillin/clavulanate is a useful option for the management of multidrug-resistant/extensively drug-resistant tuberculosis (MDR/XDR-TB); (ii) assess if meropenem/clavulanate is active against Mycobacterium tuberculosis at concentrations achievable in vivo; and (iii) determine whether there was inhibition of meropenem/clavulanate activity in the presence of amoxici...
متن کاملIn Vitro Activity of β-Lactams in Combination with β-Lactamase Inhibitors against Multidrug-Resistant Mycobacterium tuberculosis Isolates.
The combination of β-lactams and β-lactamase inhibitors has been shown to have potent in vitro activity against multidrug-resistant tuberculosis (MDR-TB) isolates. In order to identify the most potent β-lactam-β-lactamase inhibitor combination against MDR-TB, we selected nine β-lactams and three β-lactamase inhibitors, which belong to different subgroups. A total of 121 MDR-TB strains were incl...
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تاریخ انتشار 2015